Dr. Yan Shaojiu from China Aerospace Beijing Institute of Aeronautical Materials Research Institute of Graphene and Applied Research disclosed that after five years of unremitting research, the research and development team of China Aviation Aerospace Institute's graphene energy storage materials has successfully developed fast charging and long life. The new graphene lithium-ion battery with low heat generation has already realized batch preparation, and will soon be put into market application. The test results show that under the same conditions, the charging time of the new graphene lithium ion battery is only one tenth of that of ordinary lithium ion batteries, but the service life is five times that of ordinary lithium ion batteries, and the heat generation problem is effectively suppressed. If such a graphene lithium ion battery is used, the ordinary mobile phone can be fully charged in only 10 minutes. "China Aerospace Materials Institute can develop a new type of graphene lithium battery with both 'fast charge' and 'long life', which has two main reasons." Yan Shaojiu pointed out that "the first is China Aerospace Institute High-volume, high-performance, low-cost graphene powder preparation technology with independent intellectual property rights provides a material basis for the development and production of graphene lithium-ion batteries. Second, China Aerospace Institute uses unique technology to produce graphene. As a key electrode material, it is applied to lithium-ion batteries, making full use of the excellent conductivity and thermal conductivity of graphene, so that the internal resistance and working temperature rise of lithium-ion batteries are greatly reduced, thereby achieving both rapid charge and discharge and long life." The new graphene lithium battery will have important market prospects in the fields of automotive, aviation and communications. It is reported that after many years of technical research, China Aerospace Institute of Graphene and Applied Research Center has broken through the mass production of high-quality graphene and its application in many fields. In terms of graphene energy storage materials, China Aerospace Institute has been committed to the development of a new generation of high-performance energy storage devices such as graphene lithium-ion batteries and supercapacitors , lithium-sulfur batteries and fuel cells, and has achieved a series of important breakthroughs. .
Macitentan is an orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Upon administration, macitentan and its metabolites block the binding of endothelin isoform 1 (ET-1) to type-A and type-B ETR on both the tumor cells and the endothelial cells in the tumor vasculature. This prevents ET-1 mediated signaling transduction which may decrease tumor cell proliferation, progression, and angiogenesis in tumor tissue. ET-1, a potent vasoconstrictor that plays an important role in inflammation and tissue repair, is, together with its receptors, overexpressed varyingly in many tumor cell types.
Macitentan is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). Macitentan has been associated with a low rate of serum enzyme elevations during therapy, but has yet to be implicated in cases of clinically apparent acute liver injury.
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