Scientists at the A * STAR Research Institute and the Institute of Cell Biology (IMCB) have developed a method to generate human induced pluripotent stem cells (hiPS cells) by taking a drop of blood from a finger. At a press conference on Thursday, A*STAR researchers said that this new technology may increase the number and diversity of donors and promote the establishment of large hiPSC banks.


Although stem cells can also be generated from blood cells, this usually requires large amounts of blood. Scientists at the IMCB showed for the first time that a drop of blood is enough to re-induce pluripotent stem cells for humans. Since these cells display properties very similar to human embryonic stem cells, they are invaluable basic research, discovery and cell therapy. Dr Jonathan Loh Yuin Han, chief scientist of fingertip blood sampling technology, said, “Our fingertip blood sampling technology, in fact, uses less than a fingertip blood, and the remaining blood can even be used for DNA sequencing and other blood tests.”
Dr. Alexander Stuart Cook, a senior consultant and essay coordinator at the National Heart Center in Singapore, said, “We were able to distinguish Jonathan's fingertip blood sampling technique from hiPS cells that were reprogrammed for functional heart cells.”
IMCB executive director, Professor Wan Jin Hong Kong, said: "Now research on hiPS cells is very popular because it may be used as a model for studying human diseases and regenerative medicine."

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